Neutrophils and Contact Activation of Coagulation as Potential Drivers of COVID-19

Circulation. 2020 Nov 3;142(18):1787-1790. doi: 10.1161/CIRCULATIONAHA.120.050656. Epub 2020 Sep 18.

Authors

Matthias H Busch^#^{1

2}, Sjoerd A M E G Timmermans^#^{1

2}, Magdolna Nagy², Mayken Visser², Joram Huckriede², Joop P Aendekerk², Femke de Vries², Judith Potjewijd¹, Borefore Jallah¹, Renée Ysermans¹, Astrid M L Oude Lashof³, Paul H Breedveld⁴, Marcel C G van de Poll⁵, Iwan C C van de Horst⁵, Bas C T van Bussel⁵, Ruud O M F I H Theunissen², Henri M H Spronk², Jan G M C Damoiseaux⁶, Hugo Ten Cate^{7

2}, Gerry A F Nicolaes², Chris P Reutelingsperger^#², Pieter van Paassen^#^{1

2}

Affiliations

¹ Department of Nephrology and Clinical Immunology (M.H.B., S.A.M.E.G.T., J.P., B.J., R.Y., P.v.P.), Maastricht University Medical Center, The Netherlands.
² Department of Biochemistry, Cardiovascular Research Institute, Maastricht, The Netherlands (M.H.B., S.A.M.E.G.T., M.N., M.V., J.H., J.P.A., F.d.V., R.O.M.F.I.H.T., H.M.H.S., H.t.C., G.A.F.N., C.P.R., P.v.P.).
³ Department of Medical Microbiology (A.M.L.O.L.), Maastricht University Medical Center, The Netherlands.
⁴ Department of Surgery (P.H.B.), Maastricht University Medical Center, The Netherlands.
⁵ Department of Intensive Care Medicine (M.C.G.v.d.P., I.C.C.v.d.H., B.C.T.v.B.), Maastricht University Medical Center, The Netherlands.
⁶ Central Diagnostic Laboratory (J.G.M.C.D.), Maastricht University Medical Center, The Netherlands.
⁷ Thrombosis Expertise Center (H.t.C.), Maastricht University Medical Center, The Netherlands.

^# Contributed equally.

No abstract available

Keywords: COVID-19; thrombophilia.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Betacoronavirus / immunology
Betacoronavirus / pathogenicity*
Blood Coagulation*
COVID-19
Complement Activation*
Coronavirus Infections / blood
Coronavirus Infections / immunology
Coronavirus Infections / virology*
Extracellular Traps / immunology
Extracellular Traps / virology*
Female
Host-Pathogen Interactions
Humans
Male
Middle Aged
Neutrophils / immunology
Neutrophils / virology*
Pandemics
Pneumonia, Viral / blood
Pneumonia, Viral / immunology
Pneumonia, Viral / virology*
SARS-CoV-2
Thrombophilia / blood
Thrombophilia / immunology
Thrombophilia / virology*
Thrombosis / blood
Thrombosis / immunology
Thrombosis / virology*