The Gut Microbiota at the Service of Immunometabolism

Chloé Michaudel; Harry Sokol

doi:10.1016/j.cmet.2020.09.004

The Gut Microbiota at the Service of Immunometabolism

Cell Metab. 2020 Oct 6;32(4):514-523. doi: 10.1016/j.cmet.2020.09.004. Epub 2020 Sep 17.

Authors

Chloé Michaudel¹, Harry Sokol²

Affiliations

¹ INRA, UMR1319 Micalis and AgroParisTech, Jouy en Josas, France; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.
² INRA, UMR1319 Micalis and AgroParisTech, Jouy en Josas, France; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France; Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, 75012 Paris, France. Electronic address: harry.sokol@aphp.fr.

PMID: 32946809
DOI: 10.1016/j.cmet.2020.09.004

Abstract

The gut microbiota is implicated in immune system functions. Regulation of the metabolic processes occurring in immune cells is crucial for the maintenance of homeostasis and immunopathogenesis. Emerging data demonstrate that the gut microbiota is an actor in immunometabolism, notably through the effect of metabolites such as short-chain fatty acids, bile acids, and tryptophan metabolites. In this Perspective, we discuss the impact of the gut microbiota on the intracellular metabolism of the different subtypes of immune cells, including intestinal epithelial cells. Besides the effects on health, we discuss the potential consequences in infection context and inflammatory bowel diseases.

Keywords: immunity; immunometabolism; metabolism; microbiota.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Epithelial Cells / metabolism*
Gastrointestinal Microbiome
Humans
Immune System / metabolism
Inflammatory Bowel Diseases / metabolism*
Intestines / cytology