Signaling from membrane semaphorin 4D in T lymphocytes

Mol Immunol. 2021 Jan:129:56-62. doi: 10.1016/j.molimm.2020.08.009. Epub 2020 Sep 15.

Abstract

Semaphorin 4D (Sema4D) is widely represented in the immune system in both membrane and soluble form, and controls immune processes through the specific receptors - these are generally accepted views. Here, an alternative way of Sema4D-dependent immunoregulation is presented, suggesting its functioning as a receptor. We have shown that activation of membrane Sema4D induces phosphorylation of Lck/ZAP-70 in intact T lymphocytes and enhances it in stimulated T cells. Since Sema4D is constitutively presented on the membrane of T lymphocytes, and classical Sema4D receptors are highly expressed by antigen-presenting cells, the membrane Sema4D can serve as an obligate costimulatory molecule in T lymphocyte priming or T-dependent B cell activation.

Keywords: Lck; Semaphorin 4D; T lymphocytes; Tyrosine phosphorylation; ZAP-70.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigen-Presenting Cells / immunology
  • Antigens, CD / immunology*
  • B-Lymphocytes / immunology
  • Cell Line
  • Cell Membrane / immunology*
  • Humans
  • Lymphocyte Activation / immunology
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / immunology
  • Phosphorylation / immunology
  • Semaphorins / immunology*
  • Signal Transduction / immunology*
  • T-Lymphocytes / immunology*
  • ZAP-70 Protein-Tyrosine Kinase / immunology

Substances

  • Antigens, CD
  • CD100 antigen
  • Semaphorins
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
  • ZAP-70 Protein-Tyrosine Kinase