Vasopressin Neurons: Master Integrators of Time and Homeostasis

Trends Neurosci. 2020 Nov;43(11):839-841. doi: 10.1016/j.tins.2020.08.007. Epub 2020 Sep 15.


A recent article by Gizowski and Bourque shows that vasopressinergic (VP) neurons within the suprachiasmatic nucleus (SCN) master circadian clock have the ability of encoding afferent input from osmosensors and generating appropriate homeostatic responses, suggesting that SCN neurons can integrate internal circadian time and acute changes in homeostatic markers.

Keywords: circadian; internal sensors; internal time; osmosensing; suprachiasmatic nucleus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Circadian Rhythm*
  • Homeostasis
  • Neurons / metabolism
  • Suprachiasmatic Nucleus
  • Synaptic Transmission
  • Thirst*
  • Vasopressins / metabolism


  • Vasopressins