Clinical outcomes of patients with COVID-19 and HIV coinfection

J Med Virol. 2021 Mar;93(3):1687-1693. doi: 10.1002/jmv.26533. Epub 2020 Oct 14.


Background: Patients with human immunodeficiency virus (HIV) infection may be at an increased risk for morbidity and mortality from the coronavirus disease 2019 (COVID-19). We present the clinical outcomes of HIV patients hospitalized for COVID-19 in a matched comparison with historical controls.

Methods: We conducted a retrospective cohort study of HIV patients admitted for COVID-19 between March 2020 and April 2020 to Newark Beth Israel Medical Center. Data on baseline clinical characteristics and hospital course were documented and compared with that of a matched control group of COVID-19 patients who had no history of HIV. Kaplan-Meier survival curves and the log-rank tests were used to estimate and compare in-hospital survival between both unmatched and matched groups.

Results: Twenty-three patients with HIV were hospitalized with COVID-19. The median age was 59 years. The rates of in-hospital death, the need for mechanical ventilation, and intensive care unit (ICU) admission were 13% (n = 3), 9% (n = 2), and 9% (n = 2), respectively. The HIV infection was well-controlled in all patients except for three patients presented with acquired immune deficiency syndrome (AIDS). All AIDS patients were discharged home uneventfully. A one-to-one propensity matching identified 23 COVID-19 patients who served as a control group. In both pre- and post-match cohorts, survival between HIV and control groups were comparable.

Conclusions: In our cohort of HIV-infected patients hospitalized for COVID-19, there was no difference in mortality, ICU admission, and the need for mechanical ventilation when compared with a matched control of COVID-19 patients with HIV.

Keywords: AIDS; SARS-CoV-2; in-patients.

MeSH terms

  • Aged
  • COVID-19 / mortality*
  • Coinfection / mortality*
  • Comorbidity
  • Critical Care / statistics & numerical data
  • Databases, Factual
  • Female
  • HIV Infections / mortality*
  • Humans
  • Male
  • Middle Aged
  • Respiration, Artificial / statistics & numerical data
  • Retrospective Studies
  • SARS-CoV-2
  • Survival Rate
  • Treatment Outcome