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. 2020 Oct:146:104727.
doi: 10.1016/j.fitote.2020.104727. Epub 2020 Sep 18.

Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells

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Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells

Ya-Dong Qin et al. Fitoterapia. 2020 Oct.

Abstract

Two new atranones T and U (1 and 2), and three known analogues atranone B (3), atranone Q (4), and stachatranone C (5) were isolated from the toxigenic fungus Stachybotrys chartarum. Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of all the atranones (1-5) were evaluated against MG-63 human osteosarcoma cell lines. Compound 4 exhibited significant cytotoxic effect against MG-63 with IC50 value of 8.6 μM, being more active than the positive control, 5-FU (IC50 10.4 μM). Morphological features of apoptosis activities were evaluated in 4-treated MG-63 cells. Compound 4 effectively induced apoptosis of MG-63, which was associated with G0/G1-phase cell cycle arrest. Flow cytometric analysis showed that the treatment by 4 significantly induced MG-63 cell apoptosis in a dose-dependent manner.

Keywords: Apoptosis; Atranone; Cytotoxicity; Stachybotrys chartarum.

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Conflict of interest statement

Declaration of Competing Interest No conflict of interest exits in the submission of this manuscript, and manuscript is approved by all authors for publication. I would like to declare on behalf of my co-authors that the work described was original research that has not been published previously, and not under consideration for publication elsewhere, in whole or in part. All the authors listed have approved the manuscript that is enclosed. We deeply appreciate your consideration of our manuscript, and we look forward to receiving comments from the reviewers. If you have any queries, please don't hesitate to contact me at the address below.

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