Pre-extensively drug-resistant tuberculosis spondylodiscitis in an immunocompetent patient: a case report

Pan Afr Med J. 2020 Jul 8;36:165. doi: 10.11604/pamj.2020.36.165.21689. eCollection 2020.

Abstract

Pre-extensively drug resistant tuberculosis (pre-XDR-TB) has been an area of growing concern, and posing a threat to global efforts of TB control. We report a case of PreXDR-TB spondylodiscitis with resistance to a Fluoroquinolone, in an immunocompetent patient under antibacillary treatment for pleural tuberculosis, managed with drug sensitivity-based second-line antituberculous drug regimen. Our case shows the challenges of the diagnostic and management of Drug-resistant TB spondylodiscitis.

Keywords: Tuberculosis; drug-resistance; second-line treatment; spondylodiscitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antitubercular Agents / pharmacology*
  • Discitis / diagnosis
  • Discitis / drug therapy*
  • Discitis / microbiology
  • Drug Resistance, Multiple, Bacterial
  • Extensively Drug-Resistant Tuberculosis / diagnosis
  • Extensively Drug-Resistant Tuberculosis / drug therapy*
  • Extensively Drug-Resistant Tuberculosis / microbiology
  • Fluoroquinolones / pharmacology
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / isolation & purification
  • Tuberculosis, Multidrug-Resistant / drug therapy
  • Tuberculosis, Multidrug-Resistant / microbiology
  • Tuberculosis, Pleural / drug therapy*
  • Tuberculosis, Pleural / microbiology

Substances

  • Antitubercular Agents
  • Fluoroquinolones