Nitrofurantoin-Induced Pulmonary Toxicity: Always Review the Medication List

Cureus. 2020 Aug 17;12(8):e9807. doi: 10.7759/cureus.9807.


Use of nitrofurantoin for uncomplicated cystitis and recurrent urinary tract infections is common practice. While the majority of patients tolerate this medication without issue, it is important to be cognizant of adverse reactions, as these can impact patient's quality of life. Nitrofurantoin-induced pulmonary toxicity is a rare side effect that can present with various clinical manifestations, imaging abnormalities, and pathologic findings. We describe a case of chronic pneumonitis in a patient on suppressive nitrofurantoin therapy presenting with dyspnea and hypoxemia.

Keywords: chronic dyspnea on exertion; diffuse lung disease; drug-induced lung disease; nitrofurantoin; pulmonary; toxicity.

Publication types

  • Case Reports