Stereolithographic fabrication of three-dimensional permeable scaffolds from CaP/PEGDA hydrogel biocomposites for use as bone grafts

Andrey Tikhonov; Pavel Evdokimov; Elena Klimashina; Snezhana Tikhonova; Evgeny Karpushkin; Ivan Scherbackov; Vadim Dubrov; Valery Putlayev

doi:10.1016/j.jmbbm.2020.103922

Stereolithographic fabrication of three-dimensional permeable scaffolds from CaP/PEGDA hydrogel biocomposites for use as bone grafts

J Mech Behav Biomed Mater. 2020 Oct:110:103922. doi: 10.1016/j.jmbbm.2020.103922. Epub 2020 Jul 12.

Authors

Andrey Tikhonov¹, Pavel Evdokimov², Elena Klimashina², Snezhana Tikhonova³, Evgeny Karpushkin⁴, Ivan Scherbackov⁵, Vadim Dubrov⁵, Valery Putlayev²

Affiliations

¹ Department of Materials Science, Leninskie Gory 1, Building 73, Lomonosov Moscow State University, Moscow, 119991, Russia. Electronic address: andytikhon94@gmail.com.
² Department of Materials Science, Leninskie Gory 1, Building 73, Lomonosov Moscow State University, Moscow, 119991, Russia; Department of Chemistry, Leninskie Gory 1, Building 4, Lomonosov Moscow State University, Moscow, 119991, Russia.
³ Department of Materials Science, Leninskie Gory 1, Building 73, Lomonosov Moscow State University, Moscow, 119991, Russia.
⁴ Department of Chemistry, Leninskie Gory 1, Building 4, Lomonosov Moscow State University, Moscow, 119991, Russia.
⁵ Faculty of Fundamental Medicine, Lomonosovsky Prospect 31-5, Lomonosov Moscow State University, Moscow, 119991, Russia.

PMID: 32957218
DOI: 10.1016/j.jmbbm.2020.103922

Abstract

Polyethylene glycol diacrylate-based hydrogels filled with calcium phosphates (CaP, Ca/P < 1.5) were stereolithographically fabricated as three-dimensional permeable biocomposites for bone tissue regeneration, probed by several instrumental techniques (including scanning electron microscopy, infrared and UV-vis spectroscopy), and subjected to rheological/mechanical property analysis. As the CaP content increased from 0 to 10 wt%, Young's modulus and mechanical strength increased from 4 to 11 kPa and from 34 to 167 kPa, respectively. Moreover, the enhanced elastic properties and tuneable swelling behaviour of the fabricated composites made them well suited for bone defect filling.

Keywords: 3D printing; Bone regeneration; Calcium phosphate; Composite; Hydrogel.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bone Regeneration
Calcium Phosphates
Hydrogels*
Polyethylene Glycols
Tissue Engineering
Tissue Scaffolds*

Substances

Calcium Phosphates
Hydrogels
Polyethylene Glycols