Sex Determination: TRA-1 Is a Non-binary Regulator of Sexual Identity

Ronald E Ellis

doi:10.1016/j.cub.2020.07.047

Sex Determination: TRA-1 Is a Non-binary Regulator of Sexual Identity

Curr Biol. 2020 Sep 21;30(18):R1036-R1038. doi: 10.1016/j.cub.2020.07.047.

Author

Ronald E Ellis¹

Affiliation

¹ Department of Molecular Biology, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA. Electronic address: ellisre@rowan.edu.

PMID: 32961156
DOI: 10.1016/j.cub.2020.07.047

Abstract

In nematodes, TRA-1 represses the transcription of genes involved in male differentiation, allowing XX animals to undergo normal hermaphrodite development. New reports show that this transcription factor also acts in XO males, to control the differentiation of many neurons.

Publication types

Comment

MeSH terms

Animals
Caenorhabditis elegans Proteins*
Caenorhabditis elegans* / genetics
DNA-Binding Proteins
Male
Mutation
Phenotype
Sex Determination Analysis
Sex Differentiation
Transcription Factors / genetics

Substances

Caenorhabditis elegans Proteins
DNA-Binding Proteins
Transcription Factors
tra-1 protein, C elegans