Hydrogen: A Novel Option in Human Disease Treatment

Oxid Med Cell Longev. 2020 Sep 5:2020:8384742. doi: 10.1155/2020/8384742. eCollection 2020.


H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants / pharmacology
  • Apoptosis / drug effects
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections / therapy
  • Energy Metabolism / drug effects
  • Humans
  • Hydrogen / administration & dosage*
  • Hydrogen / pharmacology*
  • Oxidative Stress / drug effects
  • Pandemics
  • Pneumonia, Viral / therapy
  • Protective Agents / pharmacology
  • SARS-CoV-2


  • Anti-Inflammatory Agents
  • Antioxidants
  • Protective Agents
  • Hydrogen