The effect of abo and rh blood group antigens on admission to intensive care unit and mortality in patients with COVID-19 infection

Rev Assoc Med Bras (1992). 2020 Sep 21;66Suppl 2(Suppl 2):86-90. doi: 10.1590/1806-9282.66.S2.86. eCollection 2020.

Abstract

Aim: The aim of this study is to analyze the prognostic significance of ABO and Rh blood group antigens along with various parameters in patients followed-up with the diagnosis of COVID-19.

Methods: We evaluated 397 patients who were follow-up and treated due to COVID-19 infections. The ages, genders, chronic diseases, ABO and Rh blood group antigens, admission rates to Intensive Care Units (ICU), and mortality rates of the patients were analyzed.

Findings: The mean age of the 397 patients with COVID-19 was 47±17 years. In the blood group analysis of the patients, A Rh-positive (A +) was the most frequently seen blood type (176 patients, 44.3%) followed by O Rh-positive (0 +) (109 patients, 27,5%); 38 patients were Rh negative (Rh -) (9,6%). 53 of the patients (13,4%) were followed in ICU and 29 patients died (7,3%). Neither mortality nor admission to ICU was seen for Rh - group. The comparison of Rh groups concerning the need for ICU admission revealed a significantly high rate of ICU admission in the Rh + group (p=0,011), while no significant relationship was found between mortality and Rh antigen (p=0,069).

Conclusion: The most frequently seen blood type among COVID-19 patients was A +. The Rh + blood group was found in all cases who were admitted to ICU and had a death outcome. The Rh + blood group was found in a significantly high number of patients who were admitted to ICU, while no significant relationship was found between mortality and Rh blood group.

MeSH terms

  • Adult
  • Betacoronavirus*
  • Blood Group Antigens*
  • COVID-19
  • Coronavirus Infections / blood
  • Coronavirus Infections / mortality*
  • Female
  • Hospital Mortality
  • Humans
  • Intensive Care Units / statistics & numerical data*
  • Male
  • Middle Aged
  • Pandemics*
  • Pneumonia, Viral / blood
  • Pneumonia, Viral / mortality*
  • SARS-CoV-2

Substances

  • Blood Group Antigens