Effect of Escalating and Deescalating Financial Incentives vs Usual Care to Improve Antidepressant Adherence: A Pilot Randomized Clinical Trial

JAMA Psychiatry. 2021 Feb 1;78(2):222-224. doi: 10.1001/jamapsychiatry.2020.3000.


This pilot randomized clinical trial examines whether giving a financial incentive in an escalating or deescalating pattern (vs no incentive) to patients receiving antidepressants can enhance medication adherence.

Trial registration: ClinicalTrials.gov NCT03441399.

Publication types

  • Letter
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Antidepressive Agents / administration & dosage*
  • Depressive Disorder / drug therapy*
  • Economics, Behavioral
  • Female
  • Humans
  • Male
  • Medication Adherence*
  • Middle Aged
  • Motivation*
  • Outcome and Process Assessment, Health Care
  • Pilot Projects
  • Young Adult


  • Antidepressive Agents

Associated data

  • ClinicalTrials.gov/NCT03441399