Effect of Fundus Fluorescein Angiography on Semiautomated Aqueous Flare Measurements

Ocul Immunol Inflamm. 2022 Feb 17;30(2):424-427. doi: 10.1080/09273948.2020.1799036. Epub 2020 Sep 23.


Purpose: To evaluate the effects of fluorescein fundus angiography (FFA) on semiautomated aqueous flare measurements.

Methods: Laser flare photometer (LFP) measurements was performed at baseline, 30 min, and 4 h after the intravenous administration of sodium fluorescein dye. FFA was performed immediately after the baseline LFP measurement. LFP values at 30 min and 4 h after FFA were compared to baseline values. Mean change in LFP measurements at 30 min and 4 hafter baseline was compared between FFA arm and controls.

Results: The mean flare measurement in the FFA and control arm dropped 6% (p value = 0.002) and 9% (p value = 0.04), respectively. Mean change in LFP measurement at 30 min and 4 h after baseline was not significant between FFA arm and controls.

Conclusions: Administration of fluorescein dye does not increase LFP values. The decrease in the LFP measurement following FFA may be attributed to dilation drops.

Keywords: Laser flare photometry; aqueous flare; fluorescein angiography; uveitis.

MeSH terms

  • Aqueous Humor*
  • Fluorescein / pharmacology
  • Fluorescein Angiography
  • Humans
  • Photometry
  • Uveitis, Anterior*
  • Visual Acuity


  • Fluorescein