Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection

Kelvin Kai-Wang To; Ivan Fan-Ngai Hung; Kwok-Hung Chan; Shuofeng Yuan; Wing-Kin To; Dominic Ngai-Chong Tsang; Vincent Chi-Chung Cheng; Zhiwei Chen; Kin-Hang Kok; Kwok-Yung Yuen

doi:10.1093/cid/ciaa1368

Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection

Clin Infect Dis. 2021 May 18;72(10):e659-e662. doi: 10.1093/cid/ciaa1368.

Authors

Affiliations

¹ State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.
² Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
³ Department of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
⁴ Department of Pathology, Princess Margaret Hospital, Hong Kong Special Administrative Region, China.
⁵ Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China.

Abstract

We recently reported a patient with coronavirus disease 2019 reinfection. Here, we show that serum neutralizing antibodies could be detected during the first episode but not at the presentation of the second episode. During reinfection, neutralizing antibodies and high avidity immunoglobulin G were found within 8 days after hospitalization, whereas immunoglobulin M response was absent.

Keywords: COVID-19; SARS-CoV-2; antibody; immunity; reinfection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
COVID-19*
Humans
Immunoglobulin M
Reinfection
SARS-CoV-2

Substances

Antibodies, Neutralizing
Antibodies, Viral
Immunoglobulin M