Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning

Cancers (Basel). 2020 Sep 21;12(9):2694. doi: 10.3390/cancers12092694.


Modern drug discovery through de novo drug discovery entails high financial costs, low success rates, and lengthy trial periods. Drug repositioning presents a suitable approach for overcoming these issues by re-evaluating biological targets and modes of action of approved drugs. Coupling high-throughput technologies with genome-wide essentiality screens, network analysis, genome-scale metabolic modeling, and machine learning techniques enables the proposal of new drug-target signatures and uncovers unanticipated modes of action for available drugs. Here, we discuss the current issues associated with drug repositioning in light of curated high-throughput multi-omic databases, genome-wide screening technologies, and their application in systems biology/medicine approaches.

Keywords: drug repositioning; genomic screens; machine learning; systems medicine; systems pharmacology.

Publication types

  • Review