Hippocampal subfields and decline in activities of daily living in Alzheimer's disease and dementia with Lewy bodies

Neurodegener Dis Manag. 2020 Dec;10(6):357-367. doi: 10.2217/nmt-2020-0039. Epub 2020 Sep 23.


Background: Hippocampal atrophy is presented in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline hippocampal subfield volumes (HSv) in mild AD and DLB, and functional decline. Materials & methods: 12 HSv were computed from structural magnetic resonance images using Freesurfer 6.0 segmentation. Functional decline was assessed using the rapid disability rating scale score. Linear regressions were conducted. Results: In AD, HSv were smaller bilaterally. However, HSv were not associated with functional decline. Conclusion: Functional decline does not depend on HSv in mild AD and DLB.

Keywords: Alzheimer's disease; activities of daily living; dementia with Lewy bodies; functional decline; hippocampal subfields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living*
  • Aged
  • Alzheimer Disease / pathology*
  • Atrophy
  • Cognition
  • Female
  • Hippocampus / pathology*
  • Humans
  • Lewy Body Disease / pathology*
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Norway