Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

Hamida Hammad; Bart N Lambrecht

doi:10.1038/s41590-020-0797-z

Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

Nat Immunol. 2020 Nov;21(11):1313-1314. doi: 10.1038/s41590-020-0797-z.

Authors

Hamida Hammad^{1

2}, Bart N Lambrecht^{3

4

5}

Affiliations

¹ Laboratory of Mucosal Immunology and Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium. Hamida.hammad@ugent.be.
² Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. Hamida.hammad@ugent.be.
³ Laboratory of Mucosal Immunology and Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium.
⁴ Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
⁵ Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.

Abstract

The activation of the Notch4-Wnt-GDF15 axis in induced Tregs dampens their immunoregulatory function and turns them into Th2 and Th17 cytokine producers, allowing them to maintain ongoing allergic asthma.

Publication types

Comment

MeSH terms

Asthma*
Growth Differentiation Factor 15
Hippo Signaling Pathway
Humans
Inflammation
Licensure
Protein Serine-Threonine Kinases / genetics
Receptor, Notch4
Receptors, Notch
T-Lymphocytes, Regulatory*

Substances

GDF15 protein, human
Growth Differentiation Factor 15
NOTCH4 protein, human
Receptor, Notch4
Receptors, Notch
Protein Serine-Threonine Kinases

Grants and funding

789384/ERC_/European Research Council/International