No Relevant Analogy Between COVID-19 and Acute Mountain Sickness

High Alt Med Biol. 2020 Dec;21(4):315-318. doi: 10.1089/ham.2020.0147. Epub 2020 Sep 22.

Abstract

Berger, Marc Moritz, Peter H. Hackett, and Peter Bärtsch. No relevant analogy between COVID-19 and acute mountain sickness. High Alt Med Biol. 21:315-318, 2020.-Clinicians and scientists have suggested therapies for coronavirus disease-19 (COVID-19) that are known to be effective for other medical conditions. A recent publication suggests that pathophysiological mechanisms underlying acute mountain sickness (a syndrome of nonspecific neurological symptoms typically experienced by nonacclimatized individuals at altitudes >2500 m) may overlap with the mechanisms causing COVID-19. In this short review, we briefly evaluate this mistaken analogy and demonstrate that this concept is not supported by scientific evidence.

Keywords: SARS-CoV-2; coronavirus disease; high altitude; high-altitude cerebral edema; high-altitude pulmonary edema; hypoxemia.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Altitude Sickness* / complications
  • Altitude Sickness* / drug therapy
  • Angiotensin-Converting Enzyme 2 / metabolism
  • COVID-19 Drug Treatment*
  • COVID-19* / complications
  • Erythropoietin* / therapeutic use
  • Humans
  • Hypoxia / complications
  • Inflammation / complications
  • SARS-CoV-2
  • Symptom Assessment

Substances

  • Erythropoietin
  • Angiotensin-Converting Enzyme 2