Mapping Transplant Arteriosclerosis Cell-by-Cell: A Path to New Immune Insights

doi:10.1161/CIRCRESAHA.120.317907

Editorial

. 2020 Sep 25;127(8):994-996.

doi: 10.1161/CIRCRESAHA.120.317907. Epub 2020 Sep 24.

Mapping Transplant Arteriosclerosis Cell-by-Cell: A Path to New Immune Insights

Dawn M Fernandez¹, Chiara Giannarelli^{1

2}

Affiliations

¹ Cardiovascular Research Center (D.M.F., C.G.).
² Genetics and Genomic Sciences (C.G.), Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY.

PMID: 32970531
PMCID: PMC7518471
DOI: 10.1161/CIRCRESAHA.120.317907

Free PMC article

Editorial

Mapping Transplant Arteriosclerosis Cell-by-Cell: A Path to New Immune Insights

Dawn M Fernandez et al. Circ Res. 2020.

Free PMC article

. 2020 Sep 25;127(8):994-996.

doi: 10.1161/CIRCRESAHA.120.317907. Epub 2020 Sep 24.

Authors

Dawn M Fernandez¹, Chiara Giannarelli^{1

2}

Affiliations

¹ Cardiovascular Research Center (D.M.F., C.G.).
² Genetics and Genomic Sciences (C.G.), Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY.

PMID: 32970531
PMCID: PMC7518471
DOI: 10.1161/CIRCRESAHA.120.317907

No abstract available

Keywords: Editorials; allografts; arteriosclerosis; immune system; stem cells; tissue survival; transplants.

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Figures

**Figure 1.**
Immune cell contributions in allografts. A. Schematic of the compositional changes in major immune cell populations over time. B. Schematic of the main predicted (blue) and validated (red) interactions promoting chemotaxis.

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Comment on

Impact of Local Alloimmunity and Recipient Cells in Transplant Arteriosclerosis.
Cai J, Deng J, Gu W, Ni Z, Liu Y, Kamra Y, Saxena A, Hu Y, Yuan H, Xiao Q, Lu Y, Xu Q. Cai J, et al. Circ Res. 2020 Sep 25;127(8):974-993. doi: 10.1161/CIRCRESAHA.119.316470. Epub 2020 Jul 21. Circ Res. 2020. PMID: 32689904

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Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation.
Domblides C, Rochefort J, Riffard C, Panouillot M, Lescaille G, Teillaud JL, Mateo V, Dieu-Nosjean MC. Domblides C, et al. Front Immunol. 2021 Jun 30;12:698604. doi: 10.3389/fimmu.2021.698604. eCollection 2021. Front Immunol. 2021. PMID: 34276690 Free PMC article. Review.

References

1. Merrill JP, Murray JE, Harrison JH and Guild WR. Successful homotransplantation of the human kidney between identical twins. J Am Med Assoc. 1956;160:277–82. - PubMed
1. Enderby C and Keller CA. An overview of immunosuppression in solid organ transplantation. Am J Manag Care. 2015;21:s12–23. - PubMed
1. Mitchell RN. Graft vascular disease: immune response meets the vessel wall. Annu Rev Pathol. 2009;4:19–47. - PubMed
1. Rahmani M, Cruz RP, Granville DJ and McManus BM. Allograft vasculopathy versus atherosclerosis. Circ Res. 2006;99:801–15. - PubMed
1. Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, et al. Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J Clin Invest. 2010;120:2627–34. - PMC - PubMed

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[1] Merrill JP, Murray JE, Harrison JH and Guild WR. Successful homotransplantation of the human kidney between identical twins. J Am Med Assoc. 1956;160:277–82. - PubMed

[2] Merrill JP, Murray JE, Harrison JH and Guild WR. Successful homotransplantation of the human kidney between identical twins. J Am Med Assoc. 1956;160:277–82. - PubMed

[3] Enderby C and Keller CA. An overview of immunosuppression in solid organ transplantation. Am J Manag Care. 2015;21:s12–23. - PubMed

[4] Enderby C and Keller CA. An overview of immunosuppression in solid organ transplantation. Am J Manag Care. 2015;21:s12–23. - PubMed

[5] Mitchell RN. Graft vascular disease: immune response meets the vessel wall. Annu Rev Pathol. 2009;4:19–47. - PubMed

[6] Mitchell RN. Graft vascular disease: immune response meets the vessel wall. Annu Rev Pathol. 2009;4:19–47. - PubMed

[7] Rahmani M, Cruz RP, Granville DJ and McManus BM. Allograft vasculopathy versus atherosclerosis. Circ Res. 2006;99:801–15. - PubMed

[8] Rahmani M, Cruz RP, Granville DJ and McManus BM. Allograft vasculopathy versus atherosclerosis. Circ Res. 2006;99:801–15. - PubMed

[9] Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, et al. Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J Clin Invest. 2010;120:2627–34. - PMC - PubMed

[10] Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, et al. Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J Clin Invest. 2010;120:2627–34. - PMC - PubMed

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Mapping Transplant Arteriosclerosis Cell-by-Cell: A Path to New Immune Insights

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Mapping Transplant Arteriosclerosis Cell-by-Cell: A Path to New Immune Insights

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