The Lipidome Fingerprint of Longevity

Molecules. 2020 Sep 22;25(18):4343. doi: 10.3390/molecules25184343.

Abstract

Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species-humans included-demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life.

Keywords: fatty acids; lipidomics; longevity; membrane unsaturation; peroxidation index.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / metabolism*
  • Humans
  • Lipid Metabolism*
  • Longevity*