Association Between Parity and the Age at Menopause and Menopausal Syndrome in Northwest China

Asia Pac J Public Health. 2021 Jan;33(1):60-66. doi: 10.1177/1010539520960987. Epub 2020 Sep 25.


This study evaluated the relationships between parity and the age at menopause and menopausal syndrome among Chinese women in Gansu. A total of 7236 women aged 40 to 55 years met study eligibility criteria. The modified Kupperman Menopausal Index scale was used to assess the severity of menopausal syndrome. Cox regression was applied to estimate hazard ratio and 95% confidence interval, and logistic regression was performed to calculate odds ratio and confidence interval. The mean age at menopause was 47.91 ± 3.31 years. There is no relationship between parity and age at menopause. Women with nulliparity or multiparity seemed to have higher risks of moderate and severe menopausal syndrome. The potential beneficial effects of one or two births on menopausal syndrome were also observed by applying the multivariable logistic regression analysis, particularly in urogenital symptoms. Women with nulliparity and multiparity appeared to be at the higher risks of menopause syndrome.

Keywords: Kupperman Menopause Index; age at menopause; cross-sectional study; menopausal syndrome; parity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • China
  • Cross-Sectional Studies
  • Female
  • Humans
  • Menopause*
  • Middle Aged
  • Parity*
  • Risk Assessment
  • Severity of Illness Index