Brief Report: Bacterial Vaginosis and Risk of HIV Infection in the Context of CD101 Gene Variation

J Acquir Immune Defic Syndr. 2020 Dec 15;85(5):584-587. doi: 10.1097/QAI.0000000000002505.


Background: Whether bacterial vaginosis (BV) and CD101 immunoglobulin-like (Ig-like) variants independently increase HIV risk through mucosal inflammation is not well understood. We evaluated whether the impact of BV on HIV acquisition in women differs by the presence or absence of candidate CD101 Ig-like variants.

Methods: We used data from 2 studies of HIV serodiscordant couples in east (Kenya, Tanzania, and Uganda) and southern (Botswana, South Africa, and Zambia) Africa, which longitudinally assessed HIV acquisition (by ELISA) and BV (by Nugent score ≥7). We used previously generated CD101 sequence data for each case and control participant to create a binary variable indicating the presence/absence of any of 5 CD101 Ig-like variants.

Results: Confirming previously shown results in this cohort, Ig-like variants increased HIV-infection risk (adjusted hazard ratio [aHR], = 2.63; 95% confidence interval [CI], 1.41 to 4.89). BV was associated with 2.5-fold higher HIV-infection risk only in the absence of Ig-like variants (aHR = 2.47; 95% CI, 0.99 to 6.15; P = 0.052), whereas in the presence of Ig-like variants, BV was not associated with higher HIV-infection risk (aHR = 0.87; 95% CI, 0.35 to 2.15; P = 0.765); however, a test for interaction was nonsignificant (P = 0.116).

Conclusions: We hypothesized that both BV and CD101 Ig-like variants facilitate HIV acquisition by augmenting similar genital inflammation pathways. Our findings indicate that inflammatory mucosal effects of Ig-like variants may influence the impact of BV on HIV risk. Host-defined inflammatory pathways may be useful targets for HIV prevention.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Africa South of the Sahara / epidemiology
  • Antigens, CD / genetics*
  • Coinfection / genetics
  • Coinfection / microbiology
  • Coinfection / virology
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation / genetics
  • HIV Infections / etiology*
  • HIV Infections / genetics
  • Humans
  • Longitudinal Studies
  • Male
  • Membrane Glycoproteins / genetics*
  • Risk Factors
  • Vaginosis, Bacterial / complications*
  • Young Adult


  • Antigens, CD
  • CD101 antigen, human
  • Membrane Glycoproteins