PharmGKB Tutorial for Pharmacogenomics of Drugs Potentially Used in the Context of COVID-19

Clin Pharmacol Ther. 2021 Jan;109(1):116-122. doi: 10.1002/cpt.2067. Epub 2020 Oct 24.


Pharmacogenomics (PGx) is a key area of precision medicine, which is already being implemented in some health systems and may help guide clinicians toward effective therapies for individual patients. Over the last 2 decades, the Pharmacogenomics Knowledgebase (PharmGKB) has built a unique repository of PGx knowledge, including annotations of clinical guideline and regulator-approved drug labels in addition to evidence-based drug pathways and annotations of the scientific literature. All of this knowledge is freely accessible on the PharmGKB website. In the first of a series of PharmGKB tutorials, we introduce the PharmGKB coronavirus disease 2019 (COVID-19) portal and, using examples of drugs found in the portal, demonstrate some of the main features of PharmGKB. This paper is intended as a resource to help users become quickly acquainted with the wealth of information stored in PharmGKB.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antiviral Agents / pharmacokinetics*
  • COVID-19 Drug Treatment*
  • COVID-19* / genetics
  • Gene Ontology*
  • Humans
  • Knowledge Bases*
  • Medication Therapy Management
  • Pharmacogenetics* / education
  • Pharmacogenetics* / methods
  • Pharmacogenomic Testing / methods*
  • Precision Medicine / methods


  • Antiviral Agents