Progressive bile duct injury after thiabendazole administration

Gastroenterology. 1987 Aug;93(2):245-9. doi: 10.1016/0016-5085(87)91009-2.


A 27-yr-old man developed jaundice 2 wk after exposure to thiabendazole. Cholestasis persisted for 3 yr, at which time a liver transplant was performed. Two liver biopsy specimens and the hepatectomy specimen were remarkable for almost complete disappearance of interlobular bile ducts. Prominent fibrosis and hepatocellular regeneration were also present; however, the lobular architecture was preserved. This case represents an example of "idiosyncratic" drug-induced liver damage in which the primary target of injury is the bile duct. An autoimmune pathogenesis of the bile duct destruction is suggested.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bile Ducts / drug effects*
  • Bile Ducts / pathology
  • Cholestasis / chemically induced*
  • Cholestasis / surgery
  • Follow-Up Studies
  • Hepatectomy
  • Humans
  • Liver / drug effects*
  • Liver / pathology
  • Liver Transplantation
  • Male
  • Thiabendazole / adverse effects*


  • Thiabendazole