Prolonged Tracheal Intubation and the Association Between Patent Ductus Arteriosus and Bronchopulmonary Dysplasia: A Secondary Analysis of the PDA-TOLERATE trial

J Pediatr. 2021 Feb;229:283-288.e2. doi: 10.1016/j.jpeds.2020.09.047. Epub 2020 Oct 28.


In the PDA-TOLERATE trial, persistent (even for several weeks) moderate to large patent ductus arteriosus (PDA) was not associated with an increased risk of BPD when the infant required <10 days of intubation. However, in infants requiring intubation for ≥10 days, prolonged PDA exposure (≥11 days) was associated with an increased risk of moderate/severe BPD.

Keywords: bronchopulmonary dysplasia; patent ductus arteriosus; premature birth.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchopulmonary Dysplasia / epidemiology
  • Bronchopulmonary Dysplasia / etiology*
  • Ductus Arteriosus, Patent / complications
  • Ductus Arteriosus, Patent / therapy*
  • Female
  • Humans
  • Infant, Newborn
  • Intubation, Intratracheal / adverse effects*
  • Intubation, Intratracheal / methods*
  • Male
  • Prospective Studies
  • Respiration, Artificial*
  • Severity of Illness Index
  • Time Factors