Calibration of sodium iodide detectors and reentrant ionization chambers for 212 Pb activity in different geometries by HPGe activity determined samples

Appl Radiat Isot. 2020 Dec;166:109362. doi: 10.1016/j.apradiso.2020.109362. Epub 2020 Aug 7.

Abstract

Lead-212 is a promising radionuclide for cancer therapy, but no primary 212Pb activity standardization has been published. A need therefore exists for accurate estimation of injected doses of 212Pb activity in equilibrium with progeny, when it comes to preclinical and clinical trials. In this study, 212Pb activity was determined using a high purity germanium (HPGe) detector, which allowed the determination of geometry-specific calibration factors for commercially available reentrant ionization chambers (ICs) and sodium iodide (NaI) detectors.

Keywords: Activity calibration; HPGe; Ionization chamber; Pb-212; Sodium iodide detector.