Impact of catch-up vaccination on aluminum exposure due to new laws and post social distancing

J Trace Elem Med Biol. 2020 Dec:62:126649. doi: 10.1016/j.jtemb.2020.126649. Epub 2020 Sep 21.


Background: The COVID-19 pandemic has placed significant stressors on the medical community and on the general public. Part of this includes patients skipping well-child visits to reduce risk of exposure to SARS-CoV-2 virus. Published estimates of the duration of whole-body aluminum (Al) toxicity from vaccines in infants from birth to six months indicate that CDC's recommended vaccination schedule leads to unacceptably long periods of time in which infants are in aluminum toxicity (as measured by %AlumTox).

Methods: We utilize these established clearance and accumulation models to calculate expected per-body-weight whole-body toxicity of aluminum from vaccines considering for children of all ages under CDC's Catch-Up schedule from birth to ten years, assuming social distancing for 6 months. Our updated Pediatric Dose Limit (PDL) model assumes a linear improvement in renal function from birth to two years.

Results: Our results indicate that due diligence in considering alternative spacing and use of non-aluminum containing vaccines when possible will reduce whole body toxicity and may reduce risk of morbidity associated with exposure to aluminum.

Conclusions: While reduction or elimination of aluminum exposure from all sources is always a good idea, our results indicate that careful consideration of expected aluminum exposures during regular and Catch-Up vaccination is found to be especially important for infants and children below 2 years of age. We urge caution in the mass re-starting of vaccination under CDC's Catch-Up schedule for children under 12 months and offer alternative strategies to minimize per-day/week/month exposure to aluminum hydroxide following the COVID-19 period of isolation.

Keywords: Aluminum; COVID-19; Vaccination; Vaccines.

MeSH terms

  • Aluminum / toxicity*
  • COVID-19 / prevention & control*
  • Child
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Environmental Exposure / adverse effects
  • Humans
  • Infant
  • Male
  • Models, Biological
  • Pandemics / prevention & control*
  • Physical Distancing
  • SARS-CoV-2 / enzymology
  • Vaccination / legislation & jurisprudence
  • Viral Vaccines / adverse effects*


  • Viral Vaccines
  • Aluminum