Omega-3 Fatty Acids and Low-Dose Aspirin in the Treatment of Periodontitis and Metabolic Syndrome: Case Report

J Int Acad Periodontol. 2020 Oct 1;22(4):223-230.


Aims: To investigate the use of ω-3 fatty acids and low-dose aspirin as adjuncts to periodontal debridement in a patient with periodontitis and metabolic syndrome.

Methods: Periodontal and systemic parameters were assessed at baseline and 6 months. Gingival crevicular fluid was analyzed for interleukin (IL)-1β, IL-6 and interferon (IFN)-γ levels by multiplex ELISA at baseline, 3 and 6 months.

Results: The treatment was effective in reducing probing depth, clinical attachment level, bleeding on probing and plaque index, and glycated hemoglobin, triglycerides IL-1β, IL-6 and IFN-γ levels over time.

Conclusions: The adjunctive use of ω-3 and low-dose aspirin to periodontal debridement might have potential benefits in the treatment of periodontitis in a patient with metabolic syndrome.

Trial registration: NCT02800252.

Keywords: aspirin; diabetes; metabolic syndrome; omega-3 fatty acids; periodontitis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspirin
  • Chronic Periodontitis*
  • Fatty Acids, Omega-3*
  • Gingival Crevicular Fluid
  • Humans
  • Metabolic Syndrome* / complications
  • Metabolic Syndrome* / drug therapy
  • Periodontal Attachment Loss
  • Periodontal Index
  • Periodontal Pocket


  • Fatty Acids, Omega-3
  • Aspirin

Associated data