Role of Molecular Hydrogen in Skin Diseases and its Impact in Beauty

Curr Pharm Des. 2021;27(5):737-746. doi: 10.2174/1381612826666200925124235.


In today's society, healthy skin and a beautiful appearance are considered the foundation of general well-being. The skin is the largest organ of the body and plays an important role in protecting it against various hazards such as environmental, physical, chemical, and biological hazards. These factors include mediators that lead to oxidation reactions that produce reactive oxygen/nitrogen species and additional oxidants in the skin cells. An increase in oxidants beyond the antioxidant capacity of its defense system causes oxidative stress and chronic inflammation in the body. This response can cause further disruption of collagen fibers and hinder the functioning of skin cells that may result in the development of various skin diseases including psoriasis, atopic dermatitis, and aging. In this review, we summarized the present information related to the role of oxidative stress in the pathogenesis of dermatological disorders, and its impact on physical beauty and the daily lives of patients. We also discussed how molecular hydrogen exhibits a therapeutic effect against skin diseases via its effects on oxidative stress. Furthermore, findings from this summary review indicate that molecular hydrogen might be an effective treatment modality for the prevention and treatment of skin-related illnesses.

Keywords: Skin; beauty; dermatological disorder; molecular hydrogen; oxidants; oxidative stress; skin diseases.

Publication types

  • Review

MeSH terms

  • Beauty*
  • Humans
  • Hydrogen
  • Oxidation-Reduction
  • Oxidative Stress
  • Reactive Oxygen Species
  • Skin Diseases* / drug therapy


  • Reactive Oxygen Species
  • Hydrogen