Respiratory Microbial Co-infection With SARS-CoV-2

Bill W Massey; Karuna Jayathilake; Herbert Y Meltzer

doi:10.3389/fmicb.2020.02079

Respiratory Microbial Co-infection With SARS-CoV-2

Front Microbiol. 2020 Aug 25:11:2079. doi: 10.3389/fmicb.2020.02079. eCollection 2020.

Authors

Bill W Massey^{1

2}, Karuna Jayathilake³, Herbert Y Meltzer³

Affiliations

¹ Vikor Scientific LLC, Charleston, South Carolina, SC, United States.
² Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
³ Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL, United States.

Abstract

Co-infection with additional pathogens is a well-known feature of pandemics. We determined the prevalence and type of a wide variety of respiratory pathogens in 12,075 United States subjects tested for SARS-CoV-2 infection in March and April 2020. Infections with other respiratory pathogens, which on their own produce at least some SARS-CoV-2 symptoms including mortality, were present in both SARS-CoV-2 + and SARS-CoV-2- subjects. Non-SARS-CoV-2 infection rates were significantly higher in SARS-CoV-2 + (86%) patients than SARS-CoV-2- patients (76%) (p < 0.0001). Among the co-pathogens present in both subject groups were K. pneumoniae and M. catarrhalis which can produce serious respiratory illness on their own, Advanced age and nursing home status were associated with higher SARS-CoV-2 + and co-infection rates. Testing for the presence of co-pathogens going forward will assist in the diagnosis and optimal treatment of suspected SARS-CoV-2 respiratory infections in the current pandemic.

Keywords: COVID-19; K. pneumoniae; M. catarrhalis; SARS-CoV-2; age; nursing home; race; respiratory co-infection.