Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy

Ran Tian; Zhaosong Wang; Ruifang Niu; Hanjie Wang; Weijiang Guan; Jin Chang

doi:10.3389/fbioe.2020.01010

Tumor Exosome Mimicking Nanoparticles for Tumor Combinatorial Chemo-Photothermal Therapy

Front Bioeng Biotechnol. 2020 Aug 31:8:1010. doi: 10.3389/fbioe.2020.01010. eCollection 2020.

Authors

Ran Tian^{1

2

3}, Zhaosong Wang³, Ruifang Niu³, Hanjie Wang^{1

2}, Weijiang Guan⁴, Jin Chang^{1

2}

Affiliations

¹ School of Life Sciences, Tianjin University, Tianjin, China.
² Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin, China.
³ Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
⁴ State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, China.

Abstract

The development of biomimetic nanoparticles with functionalities of natural biomaterial remains a major challenge in cancer combination therapy. Herein, we developed a tumor-cell-derived exosome-camouflaged porous silicon nanoparticles (E-MSNs) as a drug delivery system for co-loading ICG and DOX (ID@E-MSNs), achieving the synergistic effects of chemotherapy and photothermal therapy against breast cancer. Compared with ID@MSNs, the biomimetic nanoparticles ID@E-MSNs can be effectively taken up by the tumor cell and enhance tumor accumulation with the help of the exosome membrane. ID@E-MSNs also retain the photothermal effect of ICG and cytotoxicity of DOX. Under 808 nm near infrared irradiation, ICG can produce hyperthermia to collapse E-MSNs nanovehicles, accelerate drug release, and induce tumor ablation, achieving effective chemo-photothermal therapy. In vivo results of 4T1 tumor-bearing BALB/c mice showed that ID@E-MSNs could accumulate tumor tissue and inhibit the growth and metastasis of tumor. Thus, tumor exosome-biomimetic nanoparticles indicate a proof-of-concept as a promising drug delivery system for efficient cancer combination therapy.

Keywords: biomimetic; breast cancer; combination therapy; nanovehicles; tumor exosome.