A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes

Chem Commun (Camb). 2020 Nov 4;56(85):12949-12952. doi: 10.1039/d0cc04360e. Epub 2020 Sep 28.

Abstract

A three-dimensional (3D) multipedal DNA walker triggered by the specific recognition between aptamers and proteins was developed for ultrasensitive tumor exosome sensing. A detection limit of 1 particle μL-1 was obtained with high selectivity. With the advantages of being simple, cost-effective and ultrasensitive, the biosensor offers potential for the early clinical diagnosis of tumors.

MeSH terms

  • Biosensing Techniques
  • DNA / chemistry*
  • Exosomes / chemistry*
  • Humans
  • Neoplasms / chemistry*

Substances

  • DNA