Assessment of the Haemophagocytic lymphohistiocytosis HScore in patients with COVID-19

Clin Infect Dis. 2020 Sep 28;ciaa1463. doi: 10.1093/cid/ciaa1463. Online ahead of print.


The clinical manifestation of moderate to severe COVID-19 has parallels to secondary haemophagocytic lymphohistiocytosis (HLH) both clinically and based on molecular inflammatory response. We found no evidence to support the utility of risk stratifying COVID-19 patients using risk scoring methodology designed for HLH.

Keywords: COVID-19; HLH; HScore; cytokine storm.