Non-Ductal Tumors of the Pancreas

Monogr Clin Cytol. 2020:26:92-108. doi: 10.1159/000455737. Epub 2020 Sep 28.


Non-ductal tumors of the pancreas are relatively rare tumors and include pancreatic neuroendocrine tumors (PanNETs), poorly differentiated neuroendocrine carcinomas, acinar cell carcinoma, solid pseudopapillary neoplasm, and pancreatoblastoma. These tumors have a morphology and biology that is distinct from that of ductal neoplasms of the pancreas. PanNETs are the most common tumors among this group. A brief summary of each tumor is described here with an emphasis on the clinical presentation, cytological features, tumor histology, and immunohistochemical profile. Differential diagnoses for each entity are also discussed.

Publication types

  • Review

MeSH terms

  • Carcinoma, Acinar Cell / diagnosis
  • Carcinoma, Acinar Cell / diagnostic imaging
  • Carcinoma, Acinar Cell / pathology
  • Carcinoma, Neuroendocrine / diagnosis
  • Carcinoma, Neuroendocrine / diagnostic imaging
  • Carcinoma, Neuroendocrine / pathology
  • Diagnosis, Differential*
  • Humans
  • Neuroendocrine Tumors / diagnosis*
  • Neuroendocrine Tumors / diagnostic imaging
  • Neuroendocrine Tumors / pathology
  • Pancreas / diagnostic imaging*
  • Pancreas / pathology
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / diagnostic imaging
  • Pancreatic Neoplasms / pathology

Supplementary concepts

  • Pancreatoblastoma