Renal magnesium wasting in two families with autosomal dominant inheritance

Kidney Int. 1987 May;31(5):1140-4. doi: 10.1038/ki.1987.120.

Abstract

Hypomagnesemia due to isolated renal magnesium loss was demonstrated in two unrelated families with autosomal dominant mode of inheritance. Magnesium infusions performed in two patients showed not only a reduced renal magnesium threshold but also a lowered renal tubular maximum for magnesium. All members of both families who presented with hypomagnesemia had also a lowered excretion of calcium in the urine, presumably as a consequence of increased reabsorption in Henle's loop.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / blood
  • Calcium / urine
  • Chromosome Aberrations / genetics*
  • Chromosome Aberrations / metabolism
  • Chromosome Disorders
  • Kidney / metabolism*
  • Magnesium / blood
  • Magnesium / urine
  • Magnesium Deficiency / complications
  • Magnesium Deficiency / genetics*
  • Pedigree
  • Renin / blood
  • Seizures / etiology

Substances

  • Renin
  • Magnesium
  • Calcium