Cornea thinning in two cases of ICE syndrome

BMJ Case Rep. 2020 Sep 28;13(9):e236354. doi: 10.1136/bcr-2020-236354.


We present two patients with a new finding of symmetrical corneal thinning early in the clinical course of iridocorneal endothelial syndrome. Patient 1 was evaluated for uncontrolled angle closure glaucoma of the left eye (OS) status post laser peripheral iridotomy (LPI). After placement of an Ahmed glaucomatous valve and trabeculectomy with mitomycin C were performed, the patient was diagnosed with Chandler syndrome. The patient's pachymetry at the time of diagnosis revealed stable central corneal thickness (CCT) of 481 µm of the right eye (OD) (baseline 494 µm) and central cornea thinning with CCT of 407 µm OS (baseline 486 µm). Patient 2 was evaluated for ocular hypertension and Chandler syndrome OS was diagnosed. The patient had a good short-term response to LPI and ocular hypotensive medications. This patient was also found to have thinning of his affected cornea with CCT 523 µm OD and 476 µm OS.

Keywords: Iris; anterior chamber; glaucoma; ophthalmology.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cornea / pathology*
  • Glaucoma, Angle-Closure / surgery
  • Gonioscopy
  • Humans
  • Iridocorneal Endothelial Syndrome / diagnosis*
  • Laser Therapy
  • Male
  • Middle Aged
  • Trabeculectomy