Recent advances in clinical diagnosis and treatment of male factor infertility

Postgrad Med. 2020 Dec;132(sup4):28-34. doi: 10.1080/00325481.2020.1830589. Epub 2020 Oct 28.


Infertility is a significant global health issue affecting around 8-12% of couples worldwide with male factor infertility accounting for a substantial proportion of these cases. Despite significant advances within the past few decades, an etiology for male factor infertility cannot be identified in up to 80% of patients and thus, this continues to be an area of active study. This review aims to provide an update on recent advances in the field of male infertility including semen analysis and at-home semen testing, genetics, DNA fragmentation, surgical approaches, and the rise of telemedicine in the era of COVID19.

Keywords: DNA fragmentation; Infertility; male; oligospermia; semen analysis; varicocele.

Publication types

  • Review

MeSH terms

  • DNA Fragmentation
  • Genetic Testing
  • Humans
  • Infertility, Male / diagnosis*
  • Infertility, Male / etiology
  • Infertility, Male / surgery
  • Infertility, Male / therapy*
  • Male
  • Men's Health
  • Risk Factors
  • Semen Analysis
  • Sperm Retrieval
  • Telemedicine / methods