Genetic Contributions to Acquired Epilepsies

doi:10.1177/1535759720954254

. 2021 Jan-Feb;21(1):5-13.

doi: 10.1177/1535759720954254. Epub 2020 Sep 29.

Genetic Contributions to Acquired Epilepsies

Piero Perucca^{1

2

3}, Ingrid E Scheffer^{4

5

6}

Affiliations

¹ Department of Neuroscience, Central Clinical School, 161666Monash University, Melbourne, Victoria, Australia.
² Departments of Medicine and Neurology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
³ Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.
⁴ Department of Medicine, 2281Epilepsy Research Centre, Austin Health, The University of Melbourne, Melbourne, Victoria, Australia.
⁵ Department of Paediatrics, Royal Children's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
⁶ The Florey Neuroscience and Murdoch Children's Research Institutes, Melbourne, Victoria, Australia.

PMID: 32990457
PMCID: PMC7863311
DOI: 10.1177/1535759720954254

Genetic Contributions to Acquired Epilepsies

Piero Perucca et al. Epilepsy Curr. 2021 Jan-Feb.

. 2021 Jan-Feb;21(1):5-13.

doi: 10.1177/1535759720954254. Epub 2020 Sep 29.

Authors

Piero Perucca^{1

2

3}, Ingrid E Scheffer^{4

5

6}

Affiliations

¹ Department of Neuroscience, Central Clinical School, 161666Monash University, Melbourne, Victoria, Australia.
² Departments of Medicine and Neurology, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
³ Department of Neurology, Alfred Health, Melbourne, Victoria, Australia.
⁴ Department of Medicine, 2281Epilepsy Research Centre, Austin Health, The University of Melbourne, Melbourne, Victoria, Australia.
⁵ Department of Paediatrics, Royal Children's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
⁶ The Florey Neuroscience and Murdoch Children's Research Institutes, Melbourne, Victoria, Australia.

PMID: 32990457
PMCID: PMC7863311
DOI: 10.1177/1535759720954254

Abstract

Whether genetic factors contribute to acquired epilepsies has long been controversial. Supporters observe that, among individuals exposed to seemingly the same brain insult, only a minority develops unprovoked seizures. Yet, only in relatively recent years have studies started to build a case for genetic contributions. Here, we appraise this emerging evidence, by providing a critical review of studies published in the field.

Keywords: acquired epilepsy; family history; genetics; post-traumatic epilepsy; poststroke epilepsy.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Cited by

Interleukin 4 Reduces Brain Hyperexcitability after Traumatic Injury by Downregulating TNF-α, Upregulating IL-10/TGF-β, and Potential Directing Macrophage/Microglia to the M2 Anti-inflammatory Phenotype.
Radpour M, Khoshkroodian B, Asgari T, Pourbadie HG, Sayyah M. Radpour M, et al. Inflammation. 2023 Oct;46(5):1810-1831. doi: 10.1007/s10753-023-01843-0. Epub 2023 Jun 1. Inflammation. 2023. PMID: 37259014
Imaging Genetics in Epilepsy: Current Knowledge and New Perspectives.
Wang G, Wu W, Xu Y, Yang Z, Xiao B, Long L. Wang G, et al. Front Mol Neurosci. 2022 May 30;15:891621. doi: 10.3389/fnmol.2022.891621. eCollection 2022. Front Mol Neurosci. 2022. PMID: 35706428 Free PMC article. Review.

References

1. Olafsson E, Ludvigsson P, Gudmundsson G, Hesdorffer D, Kjartansson O, Hauser WA. Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. Lancet Neurol. 2005;4(10):627–634. - PubMed
1. Christensen J. The Epidemiology of posttraumatic epilepsy. Semin Neurol. 2015;35(3):218–222. - PubMed
1. Herman ST. Epilepsy after brain insult: targeting epileptogenesis. Neurology. 2002;59(9 Suppl 5):S21–S26. - PubMed
1. Shorvon SD. The causes of epilepsy: changing concepts of etiology of epilepsy over the past 150 years. Epilepsia. 2011;52(6):1033–1044. - PubMed
1. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993;34(3):453–468. - PubMed

LinkOut - more resources

Full Text Sources

[1] Olafsson E, Ludvigsson P, Gudmundsson G, Hesdorffer D, Kjartansson O, Hauser WA. Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. Lancet Neurol. 2005;4(10):627–634. - PubMed

[2] Olafsson E, Ludvigsson P, Gudmundsson G, Hesdorffer D, Kjartansson O, Hauser WA. Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. Lancet Neurol. 2005;4(10):627–634. - PubMed

[3] Christensen J. The Epidemiology of posttraumatic epilepsy. Semin Neurol. 2015;35(3):218–222. - PubMed

[4] Christensen J. The Epidemiology of posttraumatic epilepsy. Semin Neurol. 2015;35(3):218–222. - PubMed

[5] Herman ST. Epilepsy after brain insult: targeting epileptogenesis. Neurology. 2002;59(9 Suppl 5):S21–S26. - PubMed

[6] Herman ST. Epilepsy after brain insult: targeting epileptogenesis. Neurology. 2002;59(9 Suppl 5):S21–S26. - PubMed

[7] Shorvon SD. The causes of epilepsy: changing concepts of etiology of epilepsy over the past 150 years. Epilepsia. 2011;52(6):1033–1044. - PubMed

[8] Shorvon SD. The causes of epilepsy: changing concepts of etiology of epilepsy over the past 150 years. Epilepsia. 2011;52(6):1033–1044. - PubMed

[9] Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993;34(3):453–468. - PubMed

[10] Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993;34(3):453–468. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Genetic Contributions to Acquired Epilepsies

Affiliations

Genetic Contributions to Acquired Epilepsies

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Related information

LinkOut - more resources

Full Text Sources