Occurrence of SARS-CoV-2 in the intraocular milieu

Exp Eye Res. 2020 Dec:201:108273. doi: 10.1016/j.exer.2020.108273. Epub 2020 Sep 28.


The purpose of this research is to study the intraocular occurrence of SARS-CoV-2. In postmortem examinations, aqueous humor and the vitreous samples were collected. All individuals were previously positive in nasopharyngeal swabbing and cause of death was respiratory failure due to SARS-CoV-2 infection. Testing was done using quantitative RT-PCR. We included 16 aqueous humor and 16 vitreous samples for PCR testing. None of the results was positive for SARS-CoV-2. Human GAPDH genes to verify the presence of RNA was present in all aqueous humor samples (16/16, 100%) and 15/16 (93.8%) vitreous samples. In conclusion, this case series found no evidence of SARS-CoV-2 in the intraocular milieu.

Keywords: Aqueous humor; Intraocular milieu; SARS-CoV-2; Vitreous body.

Publication types

  • Review

MeSH terms

  • Aqueous Humor / virology*
  • COVID-19 / diagnosis*
  • COVID-19 / epidemiology
  • COVID-19 / virology
  • COVID-19 Testing / methods*
  • Humans
  • RNA, Viral / analysis*
  • SARS-CoV-2 / genetics*
  • Vitreous Body / virology*


  • RNA, Viral