N6 -methyladenosine (m6 A) is one of the most common internal modifications in messenger RNA, which is necessary for cell physiological activities. A recent study shows that during mammalian hematopoietic development, loss of m6 A modification leads to the aberrant production of double-stranded RNA, which results in the abnormal activation of innate immune response, and ultimately leads to hematopoietic failure. Accordingly, m6 A modification provide us an attractive direction for us to understand mammalian hematopoietic development and innate immune response.
Keywords: M6A modification; dsRNA; hematopoietic development; innate immune response.
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