Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation

Frederick Guzman; Yasamin Fazeli; Meagan Khuu; Kelsey Salcido; Sarah Singh; Claudia A Benavente

doi:10.3390/cancers12102807

Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation

Cancers (Basel). 2020 Sep 29;12(10):2807. doi: 10.3390/cancers12102807.

Authors

Frederick Guzman¹, Yasamin Fazeli², Meagan Khuu², Kelsey Salcido², Sarah Singh², Claudia A Benavente^{1

2

3

4}

Affiliations

¹ Department of Pharmaceutical Sciences, University of California, 101 Theory #100, Irvine, CA 92617, USA.
² School of Biological Sciences, University of California, 5120 Natural Sciences II, Irvine, CA 92697, USA.
³ Department of Developmental and Cell Biology, University of California, 2011 Biological Sciences III, Irvine, CA 92697, USA.
⁴ Chao Family Comprehensive Cancer Center, University of California, 839 Medical Sciences Rd, Irvine, CA 92697, USA.

Abstract

Mutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during cell cycle exit. Beyond the ability of pRB to regulate transcription of cell cycle progression genes, pRB can remodel chromatin to exert several of its other biological roles. In this review, we discuss the diverse functions of pRB in epigenetic regulation including nucleosome mobilization, histone modifications, DNA methylation and non-coding RNAs.

Keywords: DNA methylation; E2F; RB1; chromatin; epigenetic; histone modification; miRNA; ncRNA; nucleosomes; retinoblastoma.

Publication types

Review

Abstract

Publication types

Grants and funding