A narrative review of hydrogen oncology: from real world survey to real world evidence

Med Gas Res. 2020 Jul-Sep;10(3):130-133. doi: 10.4103/2045-9912.296044.


The use of hydrogen for cancer control has made great progress in cytology and animal experiments. With the increasing number of hydrogen products on the market, larger numbers of advanced cancer patients have participated in clinical trials or received treatment at home after purchase. Our study reported a real-world survey from 82 patients with good cancer control using hydrogen products, including real world evidence from patients who received ineffective traditional treatment, patients who received traditional treatment that failed, or patients who refused traditional treatment. Two typical cases were reported herein. Subsequently, we included studies on the mechanism of hydrogen oncology. The mechanism of cancer control using hydrogen includes the inhibition of tumor cells and the activation of exhausted lymphocytes. Large-scale real world evidence has shown clinical value, and yet remains to be further developed and researched.

Keywords: RWE; RWS; cancer; hydrogen; lymphocyte; mechanism; real world evidence; real world survey.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Female
  • Humans
  • Hydrogen / administration & dosage
  • Hydrogen / chemistry*
  • Hydrogen / metabolism
  • Lymphocytes / metabolism
  • Medical Oncology
  • Neoplasms / therapy*
  • Signal Transduction
  • Surveys and Questionnaires


  • Hydrogen