Immunobiology of primary intracranial tumours. II. Analysis of lymphocyte subpopulations in patients with primary brain tumours

Clin Exp Immunol. 1977 Jul;29(1):61-6.


Circulating peripheral blood lymphocyte subpopulations were analysed in patients with primary intracranial neoplasia. Patients with tumours of glial origin demonstrated a significant depletion of E-rosetting lymphocytes whereas the quantitative lymphocyte profiles of patients with non-glial brain tumours were normal. The number of immunoglobulin and Fe receptor-bearing cells was not significantly altered in any group of patients: however, the EAC-RFC subpopulation was increased in those with malignant gliomas. Two hypotheses are suggested to explain these observations: first, the presence of cross-reacting antibody between T cells and brain (glial) cells, and secondly, the proliferation of EAC-RFC in response to malignant degeneration.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Brain Neoplasms / immunology*
  • Female
  • Humans
  • Immunoglobulin Fc Fragments
  • Immunologic Techniques
  • Leukocyte Count
  • Lymphocytes / immunology*
  • Male
  • Middle Aged
  • Neuroglia
  • Receptors, Antigen, B-Cell


  • Immunoglobulin Fc Fragments
  • Receptors, Antigen, B-Cell