Identification and Clinical Application of Immunological Receptors Targeting Mutated Antigens Expressed by Solid Tumors

Anna Pasetto

doi:10.3390/cancers12102818

Identification and Clinical Application of Immunological Receptors Targeting Mutated Antigens Expressed by Solid Tumors

Cancers (Basel). 2020 Sep 30;12(10):2818. doi: 10.3390/cancers12102818.

Author

Anna Pasetto¹

Affiliation

¹ Department of Laboratory Medicine, Division of Clinical Microbiology, ANA FUTURA, Karolinska Institutet, 14152 Huddinge, Sweden.

Abstract

In the recent years, immunotherapy has achieved impressive results utilizing different approaches, from (chimeric antigen receptor) CAR-T cells directed against CD19 for the treatment of leukemia and lymphomas to the Nobel prize-winning strategy of check-point inhibition for the treatment of several solid tumors [...].

Keywords: CAR; TCR; clinical trials; mutated antigens; solid tumors.

Publication types

Editorial