Excessive toxicities of pegylated asparaginase in pediatric acute lymphoblastic leukemia patients with high body surface area: A call for action

Pediatr Blood Cancer. 2021 Mar;68(3):e28743. doi: 10.1002/pbc.28743. Epub 2020 Oct 3.

Authors

Ilia N Buhtoiarov¹, Anthony S Zembillas¹

Affiliation

¹ Pediatric Hematology/Oncology and Bone Marrow Transplantation, Cleveland Clinic Children's Hospital, Cleveland, Ohio.

PMID: 33009863
DOI: 10.1002/pbc.28743

No abstract available

Publication types

Letter

MeSH terms

Antineoplastic Agents / adverse effects*
Asparaginase / adverse effects*
Body Surface Area*
Child
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions / etiology
Drug-Related Side Effects and Adverse Reactions / pathology*
Humans
Polyethylene Glycols / adverse effects*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology

Substances

Antineoplastic Agents
Polyethylene Glycols
pegaspargase
Asparaginase