PROTAC-DB: an online database of PROTACs

Nucleic Acids Res. 2021 Jan 8;49(D1):D1381-D1387. doi: 10.1093/nar/gkaa807.


Proteolysis-targeting chimeras (PROTACs), which selectively degrade targeted proteins by the ubiquitin-proteasome system, have emerged as a novel therapeutic technology with potential advantages over traditional inhibition strategies. In the past few years, this technology has achieved substantial progress and two PROTACs have been advanced into phase I clinical trials. However, this technology is still maturing and the design of PROTACs remains a great challenge. In order to promote the rational design of PROTACs, we present PROTAC-DB, a web-based open-access database that integrates structural information and experimental data of PROTACs. Currently, PROTAC-DB consists of 1662 PROTACs, 202 warheads (small molecules that target the proteins of interest), 65 E3 ligands (small molecules capable of recruiting E3 ligases) and 806 linkers, as well as their chemical structures, biological activities, and physicochemical properties. Except the biological activities of warheads and E3 ligands, PROTAC-DB also provides the degradation capacities, binding affinities and cellular activities for PROTACs. PROTAC-DB can be queried with two general searching approaches: text-based (target name, compound name or ID) and structure-based. In addition, for the convenience of users, a filtering tool for the searching results based on the physicochemical properties of compounds is also offered. PROTAC-DB is freely accessible at

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Databases, Chemical*
  • Drug Delivery Systems / methods*
  • Drug Discovery
  • Humans
  • Internet
  • Ligands
  • Pharmaceutical Preparations / chemistry*
  • Pharmaceutical Preparations / classification
  • Proteasome Endopeptidase Complex / drug effects*
  • Protein Binding
  • Proteolysis / drug effects
  • Small Molecule Libraries / chemistry*
  • Small Molecule Libraries / classification
  • Small Molecule Libraries / pharmacology
  • Software*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism
  • Ubiquitination / drug effects


  • Ligands
  • Pharmaceutical Preparations
  • Small Molecule Libraries
  • Ubiquitin-Protein Ligases
  • Proteasome Endopeptidase Complex