Free drug monitoring

Clin Lab Med. 1987 Jun;7(2):279-87.


The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels. These levels may be determined by equilibrium dialysis, ultrafiltration, and other techniques.

Publication types

  • Review

MeSH terms

  • Blood Proteins / metabolism
  • Humans
  • Monitoring, Physiologic*
  • Pharmaceutical Preparations / blood*
  • Protein Binding


  • Blood Proteins
  • Pharmaceutical Preparations