Frequent detection of enterovirus D68 and rhinovirus type C in children with acute respiratory infections

Sayed-Hamidreza Mozhgani; Mohsen Keshavarz; Neda Mousavi; Haideh Namdari; Vahid Salimi; Talat Mokhtari-Azad; Mohadeseh Zarei-Ghobadi; Seyed Alireza Nadji; Nastaran Ghavami; Farhad Rezaei

doi:10.1007/s10096-020-04051-y

Frequent detection of enterovirus D68 and rhinovirus type C in children with acute respiratory infections

Eur J Clin Microbiol Infect Dis. 2021 Mar;40(3):637-642. doi: 10.1007/s10096-020-04051-y. Epub 2020 Oct 3.

Authors

Affiliations

¹ Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
² Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
³ The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
⁴ Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1471613151, Iran.
⁵ Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
⁷ Virology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁸ Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1471613151, Iran. rezaie.farhad@gmail.com.

PMID: 33011904
DOI: 10.1007/s10096-020-04051-y

Abstract

This study aimed to evaluate the prevalence of human rhinoviruses (HRVs) and the emergence of enterovirus D68 (EV-D68) in children. A total of 322 nasopharyngeal swab samples were provided from children with an initial diagnosis of upper and lower respiratory tract infections. A total of 34 and 70 cases were positive for EV-D68 and HRV, respectively. The phylogenetic analysis revealed that the clades A and B are the prevalent genotypes for EV-D68 and the HRV-positive samples belong to three types including HRV-A, HRV-B, and HRV-C. The results showed that EV-D68 and HRV-C are circulating in Iran especially in the winter.

Keywords: EV-D68; Emerging disease; Genotyping; HRV; Human enterovirus D68; Human rhinoviruses.

MeSH terms

Acute Disease
Child, Preschool
Enterovirus / classification
Enterovirus / genetics
Enterovirus / isolation & purification*
Enterovirus Infections / epidemiology
Enterovirus Infections / virology*
Female
Genotype
Humans
Infant
Infant, Newborn
Iran / epidemiology
Male
Nasopharynx / virology
Odds Ratio
Phylogeny
Respiratory Tract Infections / epidemiology
Respiratory Tract Infections / virology*
Seasons

Grants and funding

31864/Tehran University of Medical Sciences and Health Services