Vitamin D and COVID-19: It is time to act

Int J Clin Pract. 2021 Mar;75(3):e13748. doi: 10.1111/ijcp.13748. Epub 2020 Oct 27.


Vitamin D (VitD) deficiency is considered a global problem and might be associated with increased susceptibility to COVID-19 illness. In the light of COVID-19 pandemic, VitD might be a promising agent for fighting the SARS-CoV-2, since VitD is involved in various pathophysiological mechanisms that occur during COVID-19 infection. High-dose VitD supplementation, particularly for risk groups, could be recommended to achieve and maintain optimal (range 40-60 ng/mL) serum 25-hydroxy vitamin D levels (marker of VitD status) both for COVID-19 prevention and treatment.

MeSH terms

  • COVID-19*
  • Humans
  • Pandemics
  • SARS-CoV-2
  • Vitamin D
  • Vitamin D Deficiency* / drug therapy
  • Vitamin D Deficiency* / epidemiology
  • Vitamin D Deficiency* / prevention & control


  • Vitamin D